Introduction: Hirsutism is a condition characterized by excess hair growth on the face, chest, and/or back in women and it is often caused by an imbalance of hormones, such as androgens. OCPs prove to be effective in reducing hirsutism in patients with PCOS by inhibiting the production of androgens and decreasing the activity of androgen receptors. OCPs may have additional benefits for patients with PCOS, such as regulating menstrual cycles, improving fertility, and reducing the risk of endometrial cancer. However, OCPs may not be suitable for all women with PCOS. Methods: The study was conducted to investigate the effectiveness of these OCPs in reducing hirsutism in PCOS patients. In the study, 80 participants were included, 40 in the intervention group and 40 in the control group. The intervention group received a combination oral contraceptive pill containing cyproterone acetate and drosperinone (COCP) for a period of 6 months, while the control group received a placebo. Hirsutism was assessed at baseline and at the end of the 6-month treatment period using the Ferriman-Gallwey score. The primary outcome measure was the change in Ferriman-Gallwey score from baseline to the end of the treatment period. Results: The mean age of participants was 27.4 years (SD ±5.3) and the majority had a BMI of 25.3 kg/m² (SD±4.5). The intervention group showed a significant reduction in the Ferriman-Gallwey score (-5.2, 95% CI -6.5 to -3.8), while the control group had a non-significant change (-1.9, 95% CI -3.3 to -0.5). Hormone levels showed changes. Patient satisfaction was high in the intervention group (90%). Statistical analysis revealed a significant difference in the Ferriman-Gallwey score (p < 0.05). The combination oral contraceptive pill effectively reduces hirsutism in PCOS patients. Conclusion: Our study demonstrates the significant reduction in hirsutism and high patient satisfaction with the COCP, highlighting its potential as a first-line treatment for women with PCOS, leading to improved well-being and quality of life. [ABSTRACT FROM AUTHOR]