In the patient, however, this trend reversed dramatically, TCR- / CD8+ lymphocytes formed the majority subset, accounting for 63% while / CD8+ lymphocytes reduced to 36.7% (Figure 2C). While B cells typically express the Syk (ZAP70 homolog) instead of ZAP70, mean ZAP70 fluorescent staining in B cells yielded a background MFI of 220. {gamma}{delta} T cell homeostasis is established in competition with {alpha}{beta} T cells and NK cells. Keywords: NBS; newborn screening; pathogenic variants; PJP; pneumocystis jirovecii; SCID; ZAP70; T cells EN NBS newborn screening pathogenic variants PJP pneumocystis jirovecii SCID ZAP70 T cells 1 5 5 10/27/23 20231001 NES 231001 PEER REVIEW The peer review history for this article is available at https://www.webofscience.com/api/gateway/wos/peer-review/10.1111/pai.14035. [Extracted from the article]