NaNO2-catalyzed reaction of cyclohexenone-MBH acetates: A convenient synthesis of 2-methylene-3-cyclohexenones.
- Resource Type
- Article
- Authors
- Jiang, Lin; Li, Lu; Li, Min; Yuan, Ming-Wei; Yuan, Ming-Long
- Source
- Synthetic Communications. Oct2023, Vol. 53 Issue 18, p1520-1528. 9p. 6 Diagrams.
- Subject
- *ACETATES
*FUNCTIONAL groups
*SODIUM nitrites
- Language
- ISSN
- 0039-7911
An efficient NaNO2-catalyzed synthesis of 2-methylene-3-cyclohexenones from easily accessible cyclohexenone-MBH acetates has been established for the first time. Target products were rapidly generated in moderate to high yields and with relatively high E/Z selectivity. Easy operation, good functional group tolerance, mild reaction conditions and the practicality of high efficiency of NaNO2 for the formation of 2-methylene-3-cyclohexenones constitute the attractive advantages of this reaction. [ABSTRACT FROM AUTHOR]