Determination of the components of danyikangtai powder into the plasma and its pharmacodynamic study.
- Resource Type
- Article
- Authors
- Li, Jing-Wei; Zhang, Yu-Meng; Zhao, Chun-Jie; Zhao, Min; Huang, Yi-He
- Source
- Journal of Asian Natural Products Research. Jul2023, Vol. 25 Issue 7, p683-696. 14p.
- Subject
- *BIOLOGICAL models
*DRUG efficacy
*IN vitro studies
*HERBAL medicine
*IN vivo studies
*HIGH performance liquid chromatography
*FLAVONOIDS
*TERPENES
*ANIMAL experimentation
*BLOOD plasma
*ALKALOIDS
*ANALYTICAL biochemistry
*RATS
*AMYLASES
*MASS spectrometry
*PANCREATITIS
*MOLECULAR structure
*CELL lines
*COLLECTION & preservation of biological specimens
*CHINESE medicine
*POWDERS
*PHARMACOKINETICS
- Language
- ISSN
- 1028-6020
Danyikangtai powder has a definite therapeutic effect on pancreatitis. However, the internal mechanism is unclear. The purpose of this experiment is to quickly identify the blood components of danyikangtai powder and evaluate its efficacy. 25 blood components were identified by comparing the components with the same mass spectrometry information from in vivo and in vitro samples. The AR42J cells of the pancreatitis model were treated with drug-containing plasma, and the drug efficacy was evaluated by investigating the amylase release rate. This study provides a scientific reference for its pharmacological research and rational clinical application. [ABSTRACT FROM AUTHOR]