Squamous cell carcinoma (SCC) is the most common histological type of laryngeal cancer. Several variants of SCC have been reported. However, how these variants differ from conventional SCC and how they should be treated remain to be elucidated. To compare the prognosis of early-stage glottic cancer among SCC variants We obtained data from 12471 cases using the Surveillance, Epidemiology, and End Results database. Disease-specific survival (DSS) and overall survival (OS) rates were estimated using the Kaplan–Meier method. A Cox proportional hazard model was used to estimate hazard ratios (HRs) according to the variants. HRs for DSS and OS compared with well-differentiated SCC were 3.83 and 3.48 for adenosquamous, 1.42 and 1.42 for basaloid, 1.14 and 1.17 for papillary, 0.85 and 0.94 for spindle, and 0.81 and 1.00 for verrucous SCC. The difference in DSS among the treatment modalities was significant in conventional and papillary SCC (p <.001 and p =.032, respectively). The prognosis of SCC variants, except for adenosquamous SCC, is comparable to that of conventional SCC.
背景:鳞状细胞癌(SCC)是最常见的组织类型喉癌。 已经报道了 SCC 的几种变体。 然而, 这些变体与通常的SCC有何不同, 以及如何治疗, 仍有待阐明。 目的:比较 SCC 变体中早期声门癌的预后。 方法:我们使用监测、流行病学和最终结果数据库, 从 12471 个病例中获得数据。使用卡普兰-迈尔法估计疾病特异性生存率 (DSS) 和总生存率 (OS)。 Cox 比例风险模型用于估计不同变体的风险比 (HR)。 结果:与分化良好的 SCC 相比, DSS 和 OS 的 HR 分别为:腺鳞状细胞 3.83 和 3.48, 基底样细胞 1.42 和 1.42, 乳头状细胞 1.14 和 1.17, 纺锤体细胞 0.85 和 0.94, 以及 疣状 SCC 为0.81 和 1.00。 对于常规的和乳头状 SCC 中, 不同治疗方式的 DSS 差异显著(分别为 p <.001 和 p =.032)。 结论:除腺鳞 SCC 外, SCC 变体的预后与常规 SCC的预后具可比性。