To investigate the role of eosinophil necroptosis in asthma, we adoptively transferred eosinophils to the airways of OVA/CFA-induced mice (Figure S2A). Abbreviation BALF Bronchoalveolar Lavage Fluid CFA Complete Freund's adjuvant DAMPs damage-associated molecular patterns EMBP Eosinophil Major Basic Protein MFI mean fluorescence intensity MLKL Mixed Lineage Kinase Domain Like Pseudokinase OVA Ovalbumin RIPK1 Receptor-interacting protein kinase 1 Asthma is a widespread inflammatory disease characterized by airway inflammation, remodeling, and hyperresponsiveness (AHR),1,2 that eosinophils are assumed to play essential roles in the development of asthma and are associated with asthma severity.3,4 Recently, accumulating evidence demonstrates that programmed cell death plays critical roles in eosinophil degranulation and pathological processes. [Extracted from the article]