New technologies and concepts including single-cell sequencing, somatic mutations, endometrial histoarchitecture and organoid models open different avenues to further understand the roles of endometrial stem/progenitor cells in endometrial dynamics and endometrial pathologies. One review has explored the role of currently identified endometrial stem/progenitor cells and bone-marrow-derived cells in establishing endometriosis lesions, taking into account the theories of endometriosis pathogenesis [[5]]. Organoids have been derived from endometriotic lesions, and their co-culture with eMSCs, together with single-cell transcriptional and somatic mutation profiling in future studies, would clarify the role of endometrial stem/progenitor cells in endometriosis [[4]]. SP cells are also candidates, as they contain both epithelial and stromal cells with stem/progenitor cell properties [[5]]. [Extracted from the article]