Optimization of Cas9 RNA sequence to reduce its unexpected effects as a microRNA sponge.
- Resource Type
- Article
- Authors
- Jiang, Junfeng; Zeng, Tao; Zhang, Li; Fan, Xingfei; Jin, Qishu; Ni, Haitao; Ye, Yusheng; Cheng, Lipeng; Li, Li; Wang, Liujun; Xu, Sha; Yang, Yu; Gu, Juan; Guo, Bing; Wang, Lei; Li, Xin; Qin, Yingyi; Li, Jiaxi; Wang, Jinjiang; Chen, Xi
- Source
- Molecular Cancer. 6/24/2022, Vol. 21 Issue 1, p1-8. 8p.
- Subject
- *NUCLEOTIDE sequence
*MICRORNA
*RNA
- Language
- ISSN
- 1476-4598
Highlights: Cas9 RNA functions as a miRNA sponge. Let-7 is the dominant regulated miRNA by Cas9 RNA. RNA sequence optimization of Cas9 by synonymous mutation improves its safety. [ABSTRACT FROM AUTHOR]