Simplifying cancer: binary pan-cancer superclasses stratified by opposite YAP/TEAD effects.
- Resource Type
- Article
- Authors
- Pearson, Joel D.; Bremner, Rod
- Source
- Molecular & Cellular Oncology. 2021, Vol. 8 Issue 5, p1-3. 3p.
- Subject
- *CANCER
*NEUROENDOCRINE tumors
*LUNG cancer
*LEUKEMIA
*CANCER treatment
- Language
- ISSN
- 2372-3556
The inherent complexity of cancer complicates treatment. Identifying higher-order principles that govern cancer biology can circumvent this problem and pinpoint broadly applicable treatment options. We recently found that opposite expression and pro- versus anti-cancer activity of a single transcriptional complex functionally stratifies cancer into binary superclasses. [ABSTRACT FROM AUTHOR]