Keywords: calcium; inflammation; pain; TRP channels EN calcium inflammation pain TRP channels 5601 5603 3 12/17/20 20201215 NES 201215 The physiologically active forms of vitamin D (25OHD and 1,25OHD) were initially thought to act exclusively via the nuclear vitamin D receptor (VDR), which regulates transcription of target genes by binding to their vitamin D response element (VDRE). Even though the contribution of partial agonist activity of vitamin D on TRPV1 in intestinal epithelia remains to be explored, the relevance of TRPV1-vitamin D interaction in intestinal calcium and magnesium absorption cannot be ruled out. [Extracted from the article]