Background & Objectives: Endotracheal intubation (ETI) in usually required during general anesthesia, but has some complications associated with it. Prevention of these complications is essential for patient satisfaction. This study aimed to compare the effects of topical lidocaine gel and tramadol gel on complications of ETI. Methodology: In this clinical trial, 200 patients scheduled for laparoscopic cholecystectomy were randomly divided into five groups. The endotracheal tube cuffs were applied different gels in the following order: Group P with 1 ml of a neutral gel, Group T1 with 1 ml of 2.5% tramadol gel, Group T2 with 1 ml of 5% tramadol gel, and Group L with 1 ml of 2% lidocaine gel. In the fifth group (Group C) no gel was used. At the end of the anesthesia, the incidence of bucking, coughing, laryngospasm and/or bronchospasm, and the intensity of sore throat were recorded and compared. Data were analyzed using SPSS 20 and Chi-square, ANOVA and Kruskal-Wallis tests. The significance level of tests was considered as p < 0.05. Results: The use of 5% tramadol gel and lidocaine gel reduced the incidence of coughing (p = 0.004), but there was no significant difference between these two kinds of gels (p = 0.108). No cases of laryngospasm were observed. There was no significant difference between the incidence of sore throat, bucking, and bronchospasm in five groups (p > 0.05). Conclusion: According to the results of this study, it seems that 5% tramadol gel decreases the incidence of coughing caused by the ETI and its impact rate is the same as with 2% lidocaine gel. But both gels don't have a significant effect on the incidence of bucking, sore throat, and bronchospasm. [ABSTRACT FROM AUTHOR]