Evaluation of chromosomal abnormalities and Y-chromosome microdeletions in 1696 Turkish cases with primary male infertility: A single-center study.
- Resource Type
- Article
- Authors
- Özdemir, Taha Reşid; Özyılmaz, Berk; Çakmak, Özgür; Kaya, Özge Özer; Köse, Can; Kırbıyık, Özgür; Keskin, Mehmet Zeynel; Koç, Altuğ; Zeyrek, Tuğba; Kutbay, Yaşar Bekir; Erdoğan, Kadri Murat; Güvenç, Merve Saka
- Source
- Turkish Journal of Urology. Mar2020, Vol. 46 Issue 2, p95-100. 6p.
- Subject
- *HUMAN reproductive technology
*INFERTILITY
*KARYOTYPES
*MEN'S health
*GENETIC mutation
*POLYMERASE chain reaction
*SEX chromosome abnormalities
- Language
- ISSN
- 1300-5804
Objective: The aim of this study was to determine the frequencies of chromosomal abnormalities and Ychromosome microdeletions in Turkish cases with primary male infertility in a single center. Material and methods: Chromosomal abnormalities and Y-chromosome microdeletions were investigated in 1696 cases with primary male infertility between 2012 and 2017. Karyotype analyzes and Y-chromosome microdeletions analyzes [azoospermia factor (AZF) regions] were performed in all cases by using standard cytogenetic methods and the multiplex polymerase chain reaction method, respectively. Results: Chromosomal abnormalities were found in 142 cases (8.4%; 142/1696). Y-chromosome microdeletions were detected in 46 cases (2.7%; 46/1696). Y-chromosome microdeletions in the AZFc region were found in 20 of 46 cases (43%). Conclusion: This study is one of the few were a large number of cases was studied in Turkey. It indicates that cytogenetic and Y-chromosome microdeletion studies should be conducted in cases with primary male infertility prior to selecting assisted reproductive techniques. [ABSTRACT FROM AUTHOR]