Higher Level of Oxidative Stress Markers in Small for Gestational Age Newborns Delivered by Cesarean Section at Term.
- Resource Type
- Article
- Authors
- Dede, Hulya; Takmaz, Ozguc; Ozbasli, Esra; Dede, Suat; Gungor, Mete
- Source
- Fetal & Pediatric Pathology. Jun2017, Vol. 36 Issue 3, p232-239. 8p.
- Subject
- *OXIDATIVE stress
*GESTATIONAL age
*CESAREAN section
*SUPEROXIDE dismutase
*MALONDIALDEHYDE
*THERAPEUTICS
RISK factors
- Language
- ISSN
- 1551-3815
Introduction: The aim of our study was to determine lipid peroxidation products and antioxidant enzyme activity in umbilical cord blood of small for gestational age (SGA) neonates. Materials and methods: Umbilical cord arterial blood samples were collected from 21-term singleton SGA newborn infants and 21 age- and sex-matched appropriate for gestational age (AGA) term neonates prospectively born by elective cesarean section for determination of malondialdehyde (MDA) as a marker of lipid peroxidation and superoxide dismutase (SOD) for antioxidant activity. Results:MDA levelswere increased (5.20 vs. 3.52 nmol/mL; p <0.001), while levels of SOD(6.24 vs. 8.99U/mL; p<0.01)were decreased in SGA neonates when compared with AGA newborn infants. Conclusions: Elevated MDA levels and decreased SOD activity in umbilical cord blood may show the possibility of insufficient protective mechanisms against increased oxidative stress in SGAneonates born by cesarean section. [ABSTRACT FROM AUTHOR]