Coupling of C(sp3)–H bonds with C(sp2)–O electrophiles: mild, general and selective.
- Resource Type
- Article
- Authors
- Gui, Yong-Yuan; Liao, Li-Li; Sun, Liang; Zhang, Zhen; Ye, Jian-Heng; Shen, Guo; Lu, Zhi-Peng; Zhou, Wen-Jun; Yu, Da-Gang
- Source
- Chemical Communications. 1/18/2017, Vol. 53 Issue 6, p1192-1195. 4p.
- Subject
- *ELECTROPHILES
*ORBITAL hybridization
*AMINE analysis
- Language
- ISSN
- 1359-7345
Herein is reported the mild and general coupling of amine/ether C(sp3)–H bonds with various kinds of C(sp2)–O electrophiles with high selectivity and efficiency. Valuable allylic/benzylic amines are generated in moderate to excellent yields. The utility of this transformation is demonstrated by a broad substrate scope (>50 examples), good functional group tolerance and facile product modification. [ABSTRACT FROM AUTHOR]