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1 .
Imaging Leucine-Rich Repeat Kinase 2 In Vivo with 18F-Labeled Positron Emission Tomography Ligand
저자
by
Zhen Chen
;
Jiahui Chen
;
Laigao Chen
;
Chi-Hyeon Yoo
;
Jian Rong
, et al.
소스
Journal of Medicinal Chemistry
. 66:1712-1724
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7 .
Cytochrome-P450-Mediated Drug–Drug Interactions of Substrate Drugs: Assessing Clinical Risk Based on Molecular Properties and an Extended Clearance Classification System
저자
by
Manthena V.S. Varma
;
Stefanus J. Steyn
.
소스
Molecular Pharmaceutics
. 17:3024-3032
Web of Science
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4 .
Striatal, Hippocampal, and Cortical Networks Are Differentially Responsive to the M4- and M1-Muscarinic Acetylcholine Receptor Mediated Effects of Xanomeline
저자
by
Christopher R Butter
;
Joshua Moon
;
John F. Harms
;
Stefanus J. Steyn
;
John T. Lazzaro
, et al.
소스
ACS Chemical Neuroscience
. 10:1753-1764
Open Access (OpenAIRE)
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7 .
Lack of Effect of Sodium Benzoate at Reported Clinical Therapeutic Concentration on
d
-Alanine Metabolism in Dogs
저자
by
Brendan Tierney
;
Stefanus J. Steyn
;
Michael Popiolek
;
Michael DeVivo
.
소스
ACS Chemical Neuroscience
. 9:2832-2837
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6 . Academic Journal
Discovery, SAR, and Pharmacokinetics of a Novel 3-Hydroxyquinolin-2(1H)-one Series of Potent d-Amino Acid Oxidase (DAAO) Inhibitors†.
저자
by
Allen J. Duplantier
;
Stacey L. Becker
;
Michael J. Bohanon
;
Kris A. Borzilleri
;
Boris A. Chrunyk
, et al.
소스
Journal of Medicinal Chemistry
. Jun2009, Vol. 52 Issue 11, p3576-3585. 10p.
Full Text (ACS)
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7 .
Design and Synthesis of γ- and δ-Lactam M1 Positive Allosteric Modulators (PAMs): Convulsion and Cholinergic Toxicity of an M1-Selective PAM with Weak Agonist Activity
저자
by
Anthony R. Harris
;
Susan M. Lotarski
;
Michael Aaron Brodney
;
Michael Popiolek
;
Catherine A. Thorn
, et al.
소스
Journal of Medicinal Chemistry
. 60:6649-6663
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7 .
Inositol Phosphate Accumulation in Vivo Provides a Measure of Muscarinic M1 Receptor Activation
저자
by
Susan M. Lotarski
;
Sarah Grimwood
;
Michael Popiolek
;
Veronica Reinhart
;
Jeremy R. Edgerton
, et al.
소스
Biochemistry
. 55:7073-7085
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7 .
LRRK2 kinase inhibitors induce a reversible effect in the lungs of non-human primates with no measurable pulmonary deficits
저자
by
Anthony A. Estrada
;
Brian K. Fiske
;
Karin Rudolph
;
Paul Galatsis
;
Stephen A. Ploch
, et al.
소스
Open Access (OpenAIRE)
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7 .
Leucine-rich Repeat Kinase 2 (LRRK2) Pharmacological Inhibition Abates α-Synuclein Gene-induced Neurodegeneration
저자
by
João Paulo Lima Daher
;
Andrew B. West
;
Warren D. Hirst
;
Stefanus J. Steyn
;
Mark S. Moehle
, et al.
소스
Journal of Biological Chemistry
. 290:19433-19444
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7 .
Predicting Clearance Mechanism in Drug Discovery: Extended Clearance Classification System (ECCS)
저자
by
Stefanus J. Steyn
;
Ayman El-Kattan
;
Manthena V.S. Varma
;
Charlotte Moira Norfor Allerton
.
소스
Pharmaceutical Research
. 32:3785-3802
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