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1 . Academic Journal
Understanding the target and evaluating the consequences of gamma-secretase modulation from in vitro models to higher-order species
저자
by
Wood, Kathleen
;
Pozdnyakov, Nikolay
;
Sylvain, Emily
;
Marconi, Michael
;
Robshaw, Ashley
, et al.
소스
In
Alzheimer's & Dementia: The Journal of the Alzheimer's Association
July 2013 9(4) Supplement:P814-P814
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7 . Academic Journal
Predicting in vivo BACE inhibitor efficacy: Are human iPS-derived neurons superior?
저자
by
Oborski, Christine
;
Engle, Sandra
;
Nolan, Charles
;
Zhang, Yao
;
Pustilnik, Leslie
, et al.
소스
In
Alzheimer's & Dementia: The Journal of the Alzheimer's Association
July 2013 9(4) Supplement:P810-P811
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7 . Academic Journal
Clinical gamma-secretase inhibitors (GSIs) alter beta-amyloid 40/42 ratio in brain and show CSF beta-amyloid rebound in vivo
저자
by
Nolan, Charles
;
Atchison, Kevin
;
Pustilnik, Leslie
;
Noell, Stephen
;
Robshaw, Ashley
, et al.
소스
In
Alzheimer's & Dementia: The Journal of the Alzheimer's Association
July 2013 9(4) Supplement:P806-P807
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7 . Academic Journal
Evaluation of beta-amyloid-lowering efficacy of a novel BACE1 inhibitor in multiple species
저자
by
Nolan, Charles
;
Atchison, Kevin
;
Robshaw, Ashley
;
Pustilnik, Leslie
;
Noell, Stephen
, et al.
소스
In
Alzheimer's & Dementia: The Journal of the Alzheimer's Association
July 2013 9(4) Supplement:P806-P806
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7 . Academic Journal
Characterization of beta-amyloid 1-40 across species following treatment with beta-secretase inhibitors
저자
by
Robshaw, Ashley
;
Atchison, Kevin
;
Ambroise, Claude
;
Nolan, Charles
;
Wood, Kathleen
, et al.
소스
In
Alzheimer's & Dementia: The Journal of the Alzheimer's Association
July 2013 9(4) Supplement:P502-P502
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7 . Academic Journal
Disconnect between brain and CSF drug exposure and beta-amyloid levels following BACE inhibition
저자
by
Gonzales, Cathleen
;
Ambroise, Claude
;
Robshaw, Ashley
;
Chang, Cheng
;
Hajos-Korcsok, Eva
, et al.
소스
In
Alzheimer's & Dementia: The Journal of the Alzheimer's Association
July 2013 9(4) Supplement:P497-P498
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7 . Academic Journal
Cross-species analysis of cerebrospinal fluid (CSF) beta-amyloid reductions by the BACE1 inhibitor PF-05297909 indicates species differences in PK/PD relationships: Relevance to clinical translation
저자
by
Hajos-Korcsok, Eva
;
Nolan, Charles
;
Robshaw, Ashley
;
Christoffersen, Curt
;
JinHua Liu
, et al.
소스
In
Alzheimer's & Dementia: The Journal of the Alzheimer's Association
July 2013 9(4) Supplement:P300-P300
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7 . Academic Journal
Acute inhibition of gamma secretase lowers abeta dimer levels in plaque-bearing PSAPP mice
저자
by
Needle, Elie
;
Atchison, Kevin
;
Nolan, Charles
;
Robshaw, Ashley
;
Breysse, Nathalie
, et al.
소스
In
Alzheimer's & Dementia: The Journal of the Alzheimer's Association
July 2011 7(4) Supplement:S393-S393
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7 . Academic Journal
Design and Synthesis of Clinical Candidate PF-06751979: A Potent, Brain Penetrant, beta-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) Inhibitor Lacking Hypopigmentation
저자
by
O'Neill, Brian T.
;
Beck, Elizabeth M.
;
Butler, Christopher R.
;
Nolan, Charles E.
;
Gonzales, Cathleen
, et al.
소스
JOURNAL OF MEDICINAL CHEMISTRY
; MAY 24 2018, 61 10, p4476-p4504, 29p.
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7 . Academic Journal
Aminomethyl-Derived Beta Secretase (BACE1) Inhibitors: Engaging Gly230 without an Anilide Functionality
저자
by
Butler, Christopher R.
;
Ogilvie, Kevin
;
Martinez-Alsina, Luis
;
Barreiro, Gabriela
;
Beck, Elizabeth M.
, et al.
소스
JOURNAL OF MEDICINAL CHEMISTRY
; JAN 12 2017, 60 1, p386-p402, 17p.
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