Journal of Biotechnology and Biodiversity; Vol. 9 No. 4 (2021): Journal of Biotechnology and Biodiversity; 384-396 Journal of Biotechnology and Biodiversity; Vol. 9 Núm. 4 (2021): Journal of Biotechnology and Biodiversity; 384-396 Journal of Biotechnology and Biodiversity; v. 9 n. 4 (2021): Journal of Biotechnology and Biodiversity; 384-396