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1 . Academic Journal
Discovery of α‑Amidobenzylboronates as Highly Potent Covalent Inhibitors of Plasma Kallikrein.
저자
by
Allison, Matthew
;
Davie, Rebecca L.
;
Mogg, Adrian J.
;
Hampton, Sally L.
;
Emsley, Jonas
, et al.
소스
ACS Medicinal Chemistry Letters; 4/11/2024, Vol. 15 Issue 4, p501-509, 9p
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7 . Academic Journal
Sebetralstat (KVD900): A Potent and Selective Small Molecule Plasma Kallikrein Inhibitor Featuring a Novel P1 Group as a Potential Oral On-Demand Treatment for Hereditary Angioedema.
저자
by
Davie, Rebecca L.
;
Edwards, Hannah J.
;
Evans, D. Michael
;
Hodgson, Simon T.
;
Stocks, Michael J.
, et al.
소스
Journal of Medicinal Chemistry; 10/27/2022, Vol. 65 Issue 20, p13629-13644, 16p
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7 . Academic Journal
Pharmacological suppression of the kallikrein kinin system with KVD900: An orally available plasma kallikrein inhibitor for the on‐demand treatment of hereditary angioedema.
저자
by
Duckworth, Edward J.
;
Murugesan, Nivetha
;
Li, Lily
;
Rushbrooke, Louise J.
;
Lee, Daniel K.
, et al.
소스
Clinical & Experimental Allergy
. Sep2022, Vol. 52 Issue 9, p1059-1070. 12p. 1 Chart, 7 Graphs, 1 Map.
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7 . Academic Journal
KVD900, an oral on-demand treatment for hereditary angioedema: Phase 1 study results.
저자
by
Maetzel, Andreas
;
Smith, Michael D.
;
Duckworth, Edward J.
;
Hampton, Sally L.
;
De Donatis, Gian Marco
, et al.
소스
Journal of Allergy & Clinical Immunology; Jun2022, Vol. 149 Issue 6, p2034-2042, 9p
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7 . Academic Journal
KVD900 as a Single Dose, Rapid, Oral Plasma Kallikrein Inhibitor for the On-Demand Treatment of Hereditary Angioedema Attacks: Pharmacokinetic and Pharmacodynamic results from a Phase 1 Single Ascending Dose Study
저자
by
Hampton, Sally L.
;
De Donatis, Gian Marco
;
Murugesan, Nivetha I.
;
Rushbrooke, Louise J.
;
Li, Lily
, et al.
소스
In
The Journal of Allergy and Clinical Immunology
February 2019 143(2) Supplement:AB39-AB39
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7 . Academic Journal
Novel oral plasma kallikrein inhibitor KV998076 is protective against intravitreal VEGF and TNF alpha induced retinal edema and neuroretinal dysfunction
저자
by
Murugesan, Nivetha
;
Clermont, Allen C.
;
Pethen, Stephen
;
Li, Lily
;
Duckworth, Edward
, et al.
소스
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
; JUN 2020, 61 7, 3p.
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7 . Academic Journal
Genetic interventions in mammalian cells; applications and uses in high-throughput screening and drug discovery
저자
by
Hampton, Sally L.
;
Kinnaird, Anne I.
.
소스
Cell Biology and Toxicology
. Feb 01, 2010 26(1):43-55
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4 . Academic Journal
A novel oral plasma kallikrein (PKal) inhibitor KV123833 blocks VEGF-mediated retinal vascular hyperpermeability in a murine model of retinal edema
저자
by
Murugesan, Nivetha
;
Clermont, Allen C.
;
Rushbrooke, Louise J.
;
Robson, Peter A.
;
Thoonen, Robrecht
, et al.
소스
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
; JUL 2018, 59 9, 3p.
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7 . Academic Journal
New Benzylureas as a Novel Series of Potent, Nonpeptidic Vasopressin V2 Receptor Agonists
저자
by
Yea, Christopher M.
;
Allan, Christine E.
;
Ashworth, Doreen M.
;
Barnett, James
;
Baxter, Andy J.
, et al.
소스
JOURNAL OF MEDICINAL CHEMISTRY
; DEC 25 2008, 51 24, p8124-p8134, 11p.
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