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1 .
Discovery and Optimization of Potent, Selective, and Brain-Penetrant 1-Heteroaryl-1H-Indazole LRRK2 Kinase Inhibitors for the Treatment of Parkinson’s Disease
저자
by
David A. Candito
;
Vladimir Simov
;
Anmol Gulati
;
Solomon Kattar
;
Ryan W. Chau
, et al.
소스
Journal of Medicinal Chemistry
. 65:16801-16817
Web of Science
Scopus
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7 .
Comprehensive Strategies to Bicyclic Prolines: Applications in the Synthesis of Potent Arginase Inhibitors
저자
by
Anandan Palani
;
Matthew Lloyd Childers
;
Qinglin Pu
;
Matthew J. Mitcheltree
;
Symon Gathiaka
, et al.
소스
ACS Med Chem Lett
Open Access (OpenAIRE)
Web of Science
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7 .
Discovery of Diaminopyrimidine Carboxamide HPK1 Inhibitors as Preclinical Immunotherapy Tool Compounds
저자
by
Joey L. Methot
;
David A Candito
;
Sheila Ranganath
;
Zangwei Xu
;
Xavier Fradera
, et al.
소스
ACS Med Chem Lett
Open Access (OpenAIRE)
Web of Science
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7 .
Conformational Strain of Macrocyclic Peptides in Ligand–Receptor Complexes Based on Advanced Refinement of Bound-State Conformers
저자
by
Alexander C. Brueckner
;
Ann E. Cleves
;
Edward C. Sherer
;
Qiaolin Deng
;
Mikhail Reibarkh
, et al.
소스
Journal of Medicinal Chemistry
. 64:3282-3298
Open Access (OpenAIRE)
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7 .
Identification of Potent Reverse Indazole Inhibitors for HPK1
저자
by
Dustin M Smith
;
Zangwei Xu
;
Joey L. Methot
;
Xavier Fradera
;
Alexander Pasternak
, et al.
소스
ACS Med Chem Lett
Open Access (OpenAIRE)
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7 .
Discovery of MK-1454: A Potent Cyclic Dinucleotide Stimulator of Interferon Genes Agonist for the Treatment of Cancer
저자
by
Wonsuk Chang
;
Michael D. Altman
;
Charles A. Lesburg
;
Samanthi A. Perera
;
Jennifer A. Piesvaux
, et al.
소스
Journal of medicinal chemistry
. 65(7)
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7 .
Oxetane Promise Delivered: Discovery of Long-Acting IDO1 Inhibitors Suitable for Q3W Oral or Parenteral Dosing
저자
by
Derun Li
;
David L. Sloman
;
Abdelghani Achab
;
Hua Zhou
;
Meredeth A. McGowan
, et al.
소스
Journal of medicinal chemistry
. 65(8)
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7 .
XGen: Real-Space Fitting of Complex Ligand Conformational Ensembles to X-ray Electron Density Maps
저자
by
Charles A. Lesburg
;
Alexander C. Brueckner
;
Qiaolin Deng
;
Ann E. Cleves
;
Edward C. Sherer
, et al.
소스
Journal of Medicinal Chemistry
. 63:10509-10528
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7 .
Structure-Guided Discovery of Aminoquinazolines as Brain-Penetrant and Selective LRRK2 Inhibitors
저자
by
Mitchell H. Keylor
;
Anmol Gulati
;
Solomon D. Kattar
;
Rebecca E. Johnson
;
Ryan W. Chau
, et al.
소스
Journal of medicinal chemistry
. 65(1)
Scopus
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7 .
Discovery of Potent and Orally Available Bicyclo[1.1.1]pentane-Derived Indoleamine-2,3-dioxygenase 1 (IDO1) Inhibitors
저자
by
Nicolas Solban
;
Alexander Pasternak
;
Qinglin Pu
;
Amy C. Doty
;
David Jonathan Bennett
, et al.
소스
ACS Med Chem Lett
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