Purpose: The use of the regenerative dermal matrix consists in the bridge between the debridement and the coverage of the lesion by means of a skin graft. We describe our experience where healing was achieved without further wound coverage in a patient in whom leg amputation was indicated. Methods: 89-year-old patient arriving in ED with a critical ischemic picture of the left lower limb Rutherford 6 with nutritional status MNA score <17. History of arterial hypertension. Weight 50 kg Height 1.60 cm. Undergoing CT angiography, revascularization was indicated with transformation of wet gangrene into dry gangrene, but with ample loss of substance of the forefoot for which the treating physician indicated leg amputation. After collective evaluation, an attempt was made to rescue the limb and she underwent necrosectomy surgery, amputation of the 2nd and 2nd toe, coverage with regenerative dermal matrix of the forefoot. After the intervention, the patient was taken in charge during the hospitalization in nursing consultancy for the outpatient continuum of care. In treatment with Clavulanic acid *Amoxicillin 1grx2 x os Wound specialist nurse (WSN) treatment. Due to an accidental fall, the patient was admitted to another facility where the local treatment continued. Results: Almost complete healing of the lesion after less than a year, despite the interruption due to hospitalization in another facility. Conclusions: Ulcer healing and limb salvage were achieved even though the lesion was not definitively covered thanks to advanced dressings and the regenerative capacity of the dermal matrix.