Aim: It is significant that students who prepare for the nursing profession must gain correct theoretical and practical knowledge. In this study, it was aimed to determine the effectiveness of different simulations, developed to teach nursing students the proper way to intramuscular medication administration. Methods: This quasi-experimental research was conducted between January 2017 and June 2017. The students' state-trait anxiety levels, exam scores and psychomotor skills, and their views on the simulation methods were assessed. Results: There were no statistically significant differences between the groups' pre-post test results (p=0.837; p>0.05). In the computer-based simulation group, students' scores for state anxiety levels were significantly lower (p=0.001; p0.01), however, their skill with intramuscular medication administration was significantly higher (p=0.001; p0.01). Conclusion: In the study, it was concluded that the computer-based method was more effective in teaching intramuscular injection in the cognitive and psychomotor areas whereas the hybrid simulation method was more effective in the affective area.