Discovery of (R)-9-ethyl-1,3,4,10b-tetrahydro-7-trifluoromethylpyrazino[2,1-a]isoindol-6(2H)-one, a selective, orally active agonist of the 5-HT2C receptor
Resource Type
Journal
Authors
Wacker, Dean A. ; Varnes, Jeffrey G. ; Malmstrom, Sarah E. ; Cao, Xueying ; Hung, Chen-Pin ; Ung, Thao ; Wu, Ginger ; Zhang, Ge ; Zuvich, Eva ; Thomas, Michael A. ; Keim, William J. ; Cullen, Mary Jane ; Rohrbach, Kenneth W. ; Qu, Qinling ; Narayanan, Rangaraj ; Rossi, Karen ; Janovitz, Evan ; Lehman-McKeeman, Lois ; Malley, Mary F. ; Devenny, James ; Pelleymounter, Mary Ann ; Miller, Keith J. ; Robl, Jeffrey A.
Source
JOURNAL OF MEDICINAL CHEMISTRY ; MAR 22 2007, 50 6, p1365-p1379, 15p.
Subject
Language
English
ISSN
00222623