Fasciolosis is an anthropozoonosis of clinical and economic importance that affects several mammals. The causative agent, Fasciola hepatica, has as an obligate intermediate host, the snail Pseudosuccinea columella; therefore, control actions against the mollusks are essential to control the disease. This study aims to evaluate the effect of volatile oils of Origanum vulgare L. and Thymus vulgaris L., both species members of Lamiaceae family, and their respective major compounds, carvacrol and thymol, as an alternative in the control of the American ribbed fluke snail. The specimens were immersed in solutions with concentrations of 0.025% (mv−1), 0.05% (mv−1), and 0.1% (mv−1) and analyzed at 30 min, 2 h, 6 h, 12 h, and 24 h in relation to motility, adhesion in the plate, response to painful stimulus, and mortality. For ovigerous masses, the interruption or not of embryonic development was analyzed, with observations every 72 h up to 18 days. All compounds promoted the mortality of mollusks and the paralysis of the embryonic development. The test constituents promoted mortality after 30 min. Histological analyses indicated the occurrence of necrosis, mainly in the digestive gland and in the albumen gland and disorganized connective tissue.Graphical abstract: