The data obtained for the first time on the influence of the sequence of metal deposition and the conditions of formation of the Re-containing component on the properties of a series of catalysts 1.9 wt % Pt–1.8 wt % Re/Ce0.75Zr0.25O2 in the water gas shift reaction are presented. It is shown that catalysts in which platinum is deposited first have a content of both metals close to the expected level and make it possible to achieve the maximum CO conversion at a lower temperature compared to a monometallic platinum catalyst. Based on the data on CO chemisorption and calculations of the reaction rate per platinum surface area, it is assumed that the role of the Re-containing phase is to a greater degree related to the stabilization of a highly dispersed platinum state, rather than to participation in the catalysis of the reaction.