Hybrid metal matrix composites are the modern age materials that are extensively employed in automotive, civil construction, and bio-medical sectors. These composites should be eco-friendly, cost-effective, and exhibited with good mechanical properties. Therefore, this paper proposes a novel hybrid metal matrix composite with Al7075-T6 as a base matrix and SiC/CR/MoS2 as three distinct reinforcements, which is fabricated through advanced vacuum-sealed bottom pouring stir casting (BPSC) technique. The various process parameters chosen for the experimental study at room temperature are silicon carbide (SiC) content (3.5 and 4.5 wt.%), crumb rubber (CR) content (0.3, 0.6, and 0.9 wt.%), molybdenum disulfide (MoS2) content (3.5, 4.5, and 5.5 wt.%), stirring speed (580, 600 and 620 rpm), stirring time (2, 5 and 8 min) and pouring temperature (670, 700 and 730 °C). The design of experiments (DoE) with Taguchi L18 orthogonal array and pooled analysis of variance (ANOVA) are also conducted to investigate the influence of process parameters on densities, porosity level, surface morphology, micro-hardness, and tensile strength of the synthesized composites. Experimental results have validated that the density and porosity are significantly revamped with the selected process parameters. In addition, the microscopic images of synthesized composites have demonstrated the better surface morphology because of the uniform dispersion of reinforcements over the base matrix which is examined through an optical microscope, x-ray diffraction (XRD), and field emission scanning electron microscope with energy-dispersive x-ray spectroscopy (SEM/FESEM-EDS) techniques. In contrast to monolithic alloy, the synthesized hybrid composite having the composition of Al7075-T6 + 3.5%SiC+0.3%CR + 5.5%MoS2 (i.e. sample no.3) attains maximum improvement with porosity content is decreased by 38.74% whereas; micro-hardness and tensile strength are increased by 34.66% and 27.82%, respectively. Besides, the pooled ANOVA has also predicted the percentage contribution of the selected process parameters for micro-hardness and tensile strength.