An integrated computational pipeline and database to support whole-genome sequence annotation
- Resource Type
- Original Paper
- Authors
- Mungall, CJ; Misra, S; Berman, BP; Carlson, J; Frise, E; Harris, N; Marshall, B; Shu, S; Kaminker, JS; Prochnik, SE; Smith, CD; Smith, E; Tupy, JL; Wiel, C; Rubin, GM; Lewis, SE
- Source
- Genome Biology. 3(12)
- Subject
- Bacterial Artificial Chromosome
Database Schema
Structure Query Language
Bacterial Artificial Chromosome Sequence
Distribute Annotation System
- Language
- English
- ISSN
- 1474-760X
We describe here our experience in annotating the Drosophila melanogaster genome sequence, in the course of which we developed several new open-source software tools and a database schema to support large-scale genome annotation. We have developed these into an integrated and reusable software system for whole-genome annotation. The key contributions to overall annotation quality are the marshalling of high-quality sequences for alignments and the design of a system with an adaptable and expandable flexible architecture.