Histone lactylation links metabolism and gene regulation
- Resource Type
- News
- Authors
- Izzo, Luke T.; Wellen, Kathryn E.
- Source
- Nature: International weekly journal of science. 574(7779):492-493
- Subject
- Epigenetics
Metabolism
- Language
- English
- ISSN
- 0028-0836
1476-4687
Cells regulate gene expression in part through the chemical labelling of histone proteins. Discovery of a label derived from lactate molecules reveals a way in which cells link gene expression to nutrient metabolism.
Lactylation is a newly discovered epigenetic modification.