Ketamine alters behavior and decreases BDNF levels in the rat brain as a function of time after drug administration
- Resource Type
- article
- Authors
- Fraga, Daiane B.; Réus, Gislaine Z.; Abelaira, Helena M.; De Luca, Renata D.; Canever, Leila; Pfaffenseller, Bianca; Colpo, Gabriela D.; Kapczinski, Flávio; Quevedo, João; Zugno, Alexandra I.
- Source
- Brazilian Journal of Psychiatry. September 2013 35(3)
- Subject
- Brain-derived-neurotrophic factor
forced swimming test
behavioral
ketamine
- Language
- English
- ISSN
- 1516-4446
Objective: To evaluate behavioral changes and brain-derived neurotrophic factor (BDNF) levels in rats subjected to ketamine administration (25 mg/kg) for 7 days. Method: Behavioral evaluation was undertaken at 1 and 6 hours after the last injection. Results: We observed hyperlocomotion 1 hour after the last injection and a decrease in locomotion after 6 hours. Immobility time was decreased and climbing time was increased 6 hours after the last injection. BDNF levels were decreased in the prefrontal cortex and amygdala when rats were killed 6 hours after the last injection, compared to the saline group and to rats killed 1 hour after the last injection. BDNF levels in the striatum were decreased in rats killed 6 hours after the last ketamine injection, and BDNF levels in the hippocampus were decreased in the groups that were killed 1 and 6 hours after the last injection. Conclusion: These results suggest that the effects of ketamine on behavior and BDNF levels are related to the time at which they were evaluated after administration of the drug.