Single and repeated-dose toxicities of anti-hypertension herb extract microcapsule (AHHEM) were evaluated according to Toxicity Test Guidelines of Korea Food and Drug Administration using Sprague-Dawley rats. For single-dose toxicity test, kneading AHHEM with sterilized water were administered orally once at dose levels of 0 and 2,000 ㎎/㎏ and examined for 14 days. No dead animals, clinical signs and abnormal necropsy findings were observed and also no significant difference in body weights was found. Therefore, the median lethal dose (LD??) of AHHEM was considered to be higher than 2,000 ㎎/㎏ in both male and female rats. For repeated-dose toxicity test, AHHEM were mixed with powder fodder and administerd orally for 28 days at dose levels of 0, 500, 1,000 and 2,000 ㎎/㎏/day. No dead animals, clinical signs and significant difference in body weights were found. In hematology, mean corpuscular hemoglobin was increased in all doses of male groups, but which was not considered as a toxicological change considering the normal ranges of red blood cell count and hemoglobin concentration. In serum biochemistry, all values were included in the normal ranges. In histopathological examinations, any dose-dependant histopathological changes caused by AHHEM were not found. Therefore, the no observed adverse effect level (NOAEL) of AHHEM was considered to be higher than 2,000 ㎎/㎏ in both male and female rats.