Ginsenoside Rg5 prevents apoptosis by modulating heme-oxygenase-1/nuclear factor E2-related factor 2 signaling and alters the expression of cognitive impairment-associated genes in thermal stress-exposed HT22 cells
- Resource Type
- Academic Journal
- Authors
- Seo-Yun Choi; Kui-Jin Kim; Ji-Hyeon Song; Boo-Yong Lee
- Source
- Journal of Ginseng Research. 2018-04 42(2):225-228
- Subject
- cognitive impairment
Ginsenoside Rg5
HT22
neuroprotection
thermal stress
- Language
- Korean
- ISSN
- 1226-8453
2093-4947
Our results suggested that thermal stress can lead to activation of hippocampal cell damage and reduction of memory-associated molecules in HT22 cells. These findings also provide a part of molecular rationale for the role of ginsenoside Rg5 as a potent cognitive impairment preventive compound in blocking the initiation of hippocampal damage.