The invention relates to novel 2-halogenated 8- and 1,8-substituted ergolene derivatives of the formula (I) and the acid addition salts thereof, pharmaceutical compositions containing them and a process for their preparation. In the formula (I) ##STR1## wherein X stands for a halogen;
R stands for a C.sub.1-4 alkyl group and
R" means a hydroxyl group; or
R stands for an acyl or substituted acyl group and
R" represents a halogen or an --OR' group, wherein
R' stands for an acyl or substituted acyl group; or
R stands for hydrogen and
R" means a halogen or an --OR' group, wherein R' stands for an acyl or substituted acyl group; and the dotted line means a double bond between the 8-9 or 9-10 positions.
The compounds of the formula (I) possess an antipsychotic and antihypoxic action and a negligable extrapyramidal side-effect.