BACKGROUND:: Bone is sensitive to dynamic strain between 15 and 30 Hz. OBJECTIVE:: To observe the beneficial influence of vibration on the bone joint disease. METHODS:: A total of 60 patients, aged 20-75 years, with bone joint diseases were randomly assigned to vibration group and control group. Whole body vibration training (3 months, 10 min/d, 5 d/week) was performed in vibration group, while the control group was kept normal life as usual. The knee function, muscle strength of lower limbs, range of motion, and bone mineral density (BMD) in 3 months were observed. RESULTS AND CONCLUSION:: A total of 60 patients were included in the final analysis. BMD of the vibration group increased obviously after vibration training (+1.2% for vertebrae and + 0.85% for femur neck, P < 0.05). Ability of femur neck to fight bone fracture increased 2.81% (P < 0.05). Effective range of knee joint motion increased 9.52% (P < 0.05) and muscle max strength of lower limbs increased 13.2% (P < 0.01). Experiment results indicate that the whole body vibration training can increase BMD and improve every index sign of knee joint.Li ZX, Ma C, Zhang CL. Influence of vibration on bone and joint diseases.Zhongguo Zuzhi Gongcheng Yanjiu yu Linchuang Kangfu. 2010;14(39): 7273-7276. [http://www.crter.cn http://en.zglckf.com]