OBJECTIVE:: Evaluate a combined technique for treating distal femoral bone defects following debridement of osteomyelitis, using an external fixator together with a short supracondylar nail. DESIGN:: Retrospective study. SETTING:: Single tertiary referral centre. METHODS:: Between 2003 and 2018, 23 patients with a mean age of 37.2 years (26 – 56) underwent surgery with the same technique to manage post-debridement defects in the distal femur due to osteomyelitis. This involved acute shortening and intramedullary fixation of the defect site, together with re-lengthening from a proximal osteotomy using simultaneous external fixation. Radiographic union, range of motion of the hip and knee, external fixation time (EFT) and index (EFI), and limb length discrepancy (LLD) were assessed. RESULTS:: The mean follow-up was 51 months (18 – 192). Union was achieved in all patients without recurrence of infection during this follow-up period. The mean knee flexion was 120° and the mean extension deficit was 5° at final follow-up. The mean LLD improved from 5.5 cm (3 to 7) to 0.5 cm (0 to 2). The mean EFI was 29.2 days/cm (20 – 50) and the mean EFT was 115 days (90-150). Radiographic scores were excellent in 15 cases, good in 6, and fair in 2. Functional scores were excellent in 14 cases, good in 7, and fair in 2. CONCLUSION:: This combined strategy was an effective method for treating distal femoral segmental bone defects after debridement of osteomyelitis, with a high rate of union and acceptable complication rates. LEVEL OF EVIDENCE:: Level IV