BACKGROUND:: Finite element analysis in biomechanics research of bone and joint has been widely used, but the finite element analysis of the distal humerus is less, and the model is rough, the method is cumbersome. OBJECTIVE:: To establish a three-dimensional finite element model of the distal humerus, and to simulate under different loading the stress distribution and strain characteristics. METHODS:: The raw data were obtained from a normal adult male. His elbow was scanned by spiral CT scans without any interval. Then the CT images were inputted into the Mimics, and produced a meshed three-dimensional surface image of the distal humerus. The three-dimensional model was inputted into the ANSYS 10.0, to create the finite element model following meshing and material property assignment. The model was constrained boundary conditions and applied axial load. Through constraining the boundary conditions and applied axial load, the stress distribution and strain results on the finite element model of the distal humerus were obtained. RESULTS AND CONCLUSION:: The finite element model of the distal humerus was established with total unit number of 6 292, total node number of 10 232. When axial load was applied, the stress of the distal humerus emphasized at the medial and lateral column regions. The results indicate that the finite element model has high accuracy, and the clinical features are consistent with those of the distal humerus, so the model can properly simulate the biomechanical properties of the distal humerus.Wang YB, Zhou XJ, Ren YJ, Zhang YQ. Three-dimensional finite element model of the distal humerus and the related biomechanics analysis.Zhongguo Zuzhi Gongcheng Yanjiu yu Linchuang Kangfu. 2011;15(22): 4002–4005. [http://www.crter.cn http://en.zglckf.com]