OBJECTIVE: The purpose of this study was to produce a method of predicting limb length discrepancy in utero. METHODS: Using available databases, we divided the femoral and tibial lengths at term by the femoral and tibial lengths at each week of gestation for each percentile. The quotients represent coefficients (multipliers) of limb segment growth at each prenatal age. RESULTS: We found the prenatal multipliers to be independent of race, percentile, and gender from as early as 12 weeksʼ gestation. The prenatal multipliers are alike for femur and tibia. CONCLUSIONS: The prenatal multiplier method allows for quick prediction of limb length discrepancy at term and at skeletal maturity from as early as 12 weeksʼ gestation. Future study is needed to validate this method clinically. Copyright ©2005 John Wiley & Sons, Ltd.