Periprocedural bleeding event is one of the most common complications after percutaneous coronary intervention (PCI). The Total Thrombus-formation Analysis System (T-TAS) was developed as a system for quantitative analysis of thrombus formation, which included 2 different chips: PL chip reflecting the thrombus formation mainly mediated by platelets (PTF), and AR chip reflecting the fibrin-rich white thrombus formation (WTF). Recently, we reported that low PTF detected by PL chip in T-TAS was significantly associated with periprocedural bleeding events after elective PCI in coronary artery disease (CAD) patients. The objective in this study was to evaluate the usefulness of combination of 2 parameters measured by PL chip and AR chip in predicting periprocedural bleeding events after elective PCI. We represented PTF as PL24-AUC10 (PL) by using PL chip, and WTF as AR10AUC30 (AR) by using AR chip. In the present study, 310 consecutive patients with CAD undergoing elective PCI treated with aspirin and clopidogrel or prasugrel were measured T-TAS parameters and divided into 4 groups: high PL - high AR, high PL - low AR, low PL - high AR, and low PL - low AR. We investigated the association between thrombogenicity and periprocedural bleeding events. Total of 36 patients had periprocedural bleeding events: 4 of 82 patients in high PL - high AR group, 6 of 72 in high PL - low AR group, 9 of 73 in low PL - low AR group, and 17 of 83 in low PL - low AR group, respectively. We revealed that low PL - low AR group had high risk of periprocedural bleeding events compared to high PL - high AR group (OR 5.02 [1.61-15.67], p=0.005). Multiple logistic regression analysis identified that low hemoglobin level (OR 0.72 [0.62-0.39], p<0.001), use of prasugrel (OR 3.10 [1.52-6.33], p=0.002), maintenance dose of antiplatelet therapy (OR 1.79 [1.08-2.95], p=0.023) were associated with low PL, and that low hemoglobin level (OR 0.86 [0.74-1.00], p=0.048), low platelet count (OR 0.99 [0.98-0.99], p<0.001), use of anticoagulant (OR 3.84 [1.74-8.47], p=0.001) were associated with low AR. In conclusion, T-TAS could detect high risk patients with periprocedural bleeding events after PCI by combining 2 different chips.