Molecular pathology of allergic disease: I: Lower airway disease
- Resource Type
- Academic Journal
- Authors
- Hamid, Qutayba A.; Minshall, Eleanor M.
- Source
- The Journal of Allergy and Clinical Immunology. Jan 01, 2000 105(1, Part 1 Suppl):20-36
- Subject
- Language
- English
- ISSN
- 0091-6749
ABSTRACT: Asthma is a complex disorder associated with eosinophil infiltration and the activation of T lymphocytes within the airways. Recent advances in the pathophysiologic mechanisms of asthma point to the importance of eosinophil-basophil progenitor cells and a family of transcription factors that underlie the development of TH2-type responses. Further research is needed to address the development of chronic inflammatory changes, the role of profibrotic cytokines, and especially their reliance on eosinophils in the lungs.