Objective: To investigate the degree to which cognition, psychopathology, and level of acculturation were associated with understanding of information during the consent process for schizophrenia research. Method: Subjects were 32 Latinos with schizophrenia participating in an ongoing study of informed consent. All assessments and procedures were administered in the participantʼs preferred language (17 English, 15 Spanish). Measures included a composite cognitive score from a brief test battery (Hopkins Verbal Learning Test, Digit Symbol, Letter Number Sequencing, Trial Making Parts A and B, and Stroop Color Word Interference), as well as the Positive and Negative Syndrome Scale (PANSS), Hamilton Depression Rating Scale (HAM-D), and the Marin Acculturation Scale. Comprehension of consent information was measured with the UCSD Brief Assessment of Consent Capacity (UBACC). Results: The strongest Pearsonʼs r correlation of the UBACC was the composite cognitive score (r = .66, p < .001), followed by severity of negative symptoms from the PANSS (r = −.42, p = .023). There were no significant correlations between understanding and severity of positive symptoms (r = .12, p = .553), depressive symptoms (r = −.14, p = .522), or acculturation (r = .05, p = .812). Conclusion: Cognitive functioning is the strongest predictor of comprehension during the research consent process. These findings confirm and extend the patterns seen in studies of English-speaking (predominantly non-Latino white) patients. Researchers may need to consider participantsʼ level of cognitive functioning when conducting the informed consent process.