Formation of Multilayered Vesicles from Water/Organic-Solvent (W/O) Emulsions: Theory and Practice
- Resource Type
- Academic Journal
- Authors
- Pidgeon, Charles; Hunt, Ann H.; Dittrich, Katherine
- Source
- Pharmaceutical Research. Feb 01, 1986 3(1):23-34
- Subject
- Language
- English
- ISSN
- 0724-8741
Multilayered liposome (MLV) formation from water/organic-solvent (W/O) emulsions was studied. A fundamental liposome population parameter, the E, was defined and used to estimate the bilayer number and water spacing in MLV liposomes. MLVs prepared from W/O emulsions have optimum drug entrapment at an emulsion-lipid/emulsion-water ratio of ∼0.33. Drug entrapment is typically 50 to 65% under these optimal conditions.