Proanthocyanidins attenuate breast cancer-induced bone metastasis by inhibiting Irf-3/c-jun activation
- Resource Type
- Academic Journal
- Authors
- Guo, Shuangfei; Zhu, Wei; Yin, Ziqing; Xiao, Ding; Zhang, Qiang; Liu, Tang; Ni, Jiangdong; Ouyang, Zhengxiao; Xie, Hongming
- Source
- Anti-Cancer Drugs. Nov 01, 2019 30(10):998-1005
- Subject
- Language
- English
- ISSN
- 0959-4973
We have previously demonstrated the pivotal role of Jnk-mediated Irf-3/c-Jun in regulating nuclear factor kappa-Β ligand (RANKL)-induced osteoclastogenesis. Here, we demonstrated that proanthocyanidins (PACs) target Irf-3 to alleviate breast cancer-induced activation of osteoclasts. We also found that PACs induced apoptosis of osteoclast precursors by upregulating the ratio of bax/bcl-2 and activating caspase-3 activity. Such bone protective effect also could be observed in a bone metastasis model of breast cancer. These findings provided a novel therapeutic intervention targeting abnormal bone metabolism to alleviate bone metastasis of breast cancer.