The purpose of this review study is to evaluate sexual function and its effective factors in menopause. A systematic review was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The key words of “menopause,â€â€œpostmenopause,â€â€œpostmenopausal,â€â€œpremenopause,â€â€œpre-menopausal period,â€â€œsexual function,â€â€œsexual health,â€â€œsexuality,â€â€œsexual and gender disorders,â€â€œsexual development,â€â€œsexual dysfunction,â€â€œsexual disorders,â€â€œsexual behavior and “sexual activity†were used in combination with the Boolean operators OR and AND. After reviewing the selected articles, 27 papers were selected based on the criteria for entering the study and the goals set. The results of the reviewed articles showed that, in the physical domain, the factors affecting sexual function can be mentioned, age, hormonal changes, medical problems and reproductive history. Sexual disorders in menopause can be affected by some of the individual and social characteristics and psychological problems. Considering the fact that many psychological and social injuries occur in this period following sexual disorders; therefore, policies and programs for improving the quality of life of women in menopause should be aimed at eliminating sexual dysfunction, correcting attitudes and negative emotions and help to women for more comfortable in menopause.