The purpose of this research is to find out the effect of Megadose pharmacopuncture with Korean Medicine Treatment on patients who were diagnosed as ThoracoLumbar Junction Syndrome. Megadose pharmacopuncture was proceeded on 4 patients who received treatment at OO Korean Medicine Hospital from November, 2016 to Februrary, 2017. In addition, We also kept a record of NRS, ODI, and EQ-5D on the day of admission and discharge to find out the differences between initial and final figures. As a result, Megadose parmacopuncture showed a significant effect on alleviating pain on patients with ThoracoLumbar Junction Syndrome. There was a significant decrease in NRS, ODI scores. Not only did the scores of NRS and ODI decrease significantly,but also the figures of EQ-5D increased significantly as well. To be specific, the mean of NRS and ODI dcreased from 10 to 1.75 and 61.87 to 12.78 while the mean of EQ-5D increased from 0.258 to 0.850. This research suggests Megadose pharmacopuncture with Korean Medicine Treatment could be a remedy for ThoracoLumbar Junction Syndrome. (J Korean Med Rehabil 2018;28(2): 127-134)