This paper constructed the evaluation indicator system of local higher education development and regional economic growth,then took Xinjiang Uyghur Autonomous Region as an empirical research object. The paper measured coupling development(Scale of education, quality of education, level of teachers) of local higher education development and regional economic growth (Economic scale, economic structure, economic development)by coupling coordination model. Higher education in the region has been at a low level of development, while economic development has been supported by policies to maintain rapid growth and basically reach an upper middle class status by 2020. The economic development of Xinjiang has continued to grow and reached an Upper-middle level. After ten years of development, the coupling coordination degree of these two was Lower coordinated, and the development of higher education lagged behind regional economic growth. Measures such as increasing asset investment, increasing the number of colleges and universities, and actively bringing in and retaining talent need to be taken as soon as possible. Let higher education accelerate and overtake development to provide effective support for regional economic growth and maintain a state of high-quality coordination between the two.