Introduction: The stroke continues to be the leading cause of death, being the most preventable on the developed countries. The presence of comorbilities increase the risk of a new event, especially with Diabetes Mellitus(DM), Hypertension(HT) and Hypercholesterolemia( HCh) which increase the arterial wall rigidity, leading to a higher cardiovascular risk. The contribution of each individual risk factor potentiates the development of another stroke, with some of them contributing more for those events. The main objective is to evaluate the relationship between lesions of the target organ and lesion markers, which include the tunica intima-media thickness(TI-MT), pulse pressure(PP) and fi brinogen(FBG). Material and Methods: 140 patients with HT, 70 patients had a stroke in the last 6 month and 70 patients without any serious condition. All the patients were evaluated, taken blood samples and measured the aortic pressure and the carotid artery TI-MT. The T-Student method was used with signifi cant values of p<0,01 (“two-tailed probabilities”). Results: Both groups were similar regarding the age, sex, body mass index, drinking and smoking habits and peripheral arterial pressures. The patients with stroke showed an increase in number of: non-dipper HT patients (13%vs42% p<0.001); presence of DM (24%vs65%, p<0.001); brachial pulse pressure (53,2±10.5 vs 63.4±13.1mmHg, p<0.01); central pulse pressure (39.2±12.4 vs 52.7±15.3 mmHg, p<0.01); increase of the carotid artery TI-MT (0.6 ±0.07 vs 0.83±0.07mm, p<0.01); and Fibrinogen (326±93 vs 405±112mmg/dl, p<0.01). Conclusion: Our study determined that patients with target organ lesions, the variables that show vascular lesions are slightly increased. There was an increase of arterial lesions, development of vessels rigidity and alteration of their own microstructure, followed by a possible increase of the infl ammatory response. The main risk factors contributing for development of strokes were the non-dipper hypertension and Diabetes Mellitus.