Targeting Histamine Receptors in Irritable Bowel Syndrome: A Critical Appraisal
- Resource Type
- Article
- Authors
- Adam Fabisiak; Jakub Wlodarczyk; Natalia Fabisiak; Martin Storr; Jakub Fichna
- Source
- Journal of Neurogastroenterology and Motility. Jul 31, 2017 23(3):341
- Subject
- Ebastine
Irritable bowel syndrome
Mast cells
Receptors
histamine
- Language
- English
- ISSN
- 2093-0879
Irritable bowel syndrome is a group of functional gastrointestinal disorders with not yet fully clarified etiology. Recent evidence suggesting that mast cells may play a central role in the pathogenesis of irritable bowel syndrome paves the way for agents targeting histamine receptors as a potential therapeutic option in clinical treatment. In this review, the role of histamine and histamine receptors is debated. Moreover, the clinical evidence of anti-histamine therapeutics in irritable bowel syndrome is discussed. (J Neurogastroenterol Motil 2017;23:341-348)