This study was conducted to examine the effects of Salvia plebeia R. Br. growth and phytochemicals as affected by ratio of red and blue light in a closed-type plant production system (CPPS). Salvia plebeia R. Br. seedlings were transplanted into a deep floating technique system with a recycling nutrient solution (pH 6.5 and EC 1.5 dS·m-1). The plants were cultured during 34 days under temperature 25 ± 1°C, a photoperiod of 12/12 hours (light/dark), and a light intensity of 180 μmol·m-2·s-1 photosynthetic photon flux density provided various light quality in a CPPS. The light treatment was FL (fluorescent lamp, control), R (monochromatic red), B (monochromatic blue), R7B3 (red : blue = 7 : 3), R5B5 (red : blue = 5 : 5), and R3B7 (red : blue = 3 : 7). The growth characteristics of Salvia plebeia R. Br. such as leaf length, leaf area, fresh and dry weights of shoot were the greatest in R and R7B3. The leaf shape index was the highest in B, and specific leaf weight was lower in FL and B than in other light treatments. The photosynthesis rate was the greatest in R7B3. The total phenolic and flavonoid concentrations of Salvia plebeia R. Br. were higher in combined light than in control and monochromatic light. However, the antioxidant activity was the highest in FL. In conclusion, the results suggested that R7B3 was the most effective light treatment for production of high quality Salvia plebeia R. Br. in a CPPS.