Purpose: This study highlights the importance of emphasizing entrepreneurship and sustainability among managers to address the challenges of Industry 6.0, especially in situations of increasing environmental uncertainty. The research model reveals the important structural relationship between entrepreneurship, sustainability, and innovation performance, and through empirical analysis, we sought to confirm that entrepreneurship in the 6th industry is related to technological innovation. Methods: A survey was conducted targeting 6th industry entrepreneurs, and the relationship was analyzed using SPSS and AMOS. Results: Despite a non-significant direct relationship between entrepreneurship and innovation performance, a notable effect of sustainability on innovation performance was identified. This highlights the fact that entrepreneurship contributes to firm performance through innovation activities, especially in the form of technological innovation. Conclusion: This study highlights the essential characteristics of entrepreneurship and sustainability, highlights their interconnectedness and suggests that their inclusion in the same management activities improves performance.