Background: Colon cancer accounts for number of cases, a superior of the cause of death like gastric cancer, lung cancer. Wereport aggregates the multiple neoplasms including hematological malignancy and colon cancer. Methods: In the case that hematologic malignancy was diagnosed in our hospital by 1988 from 2013, The multiple cancer including colon cancer and the hematologic malignancy was 45 cases. So we reviewed and reported. Results: All cases are 45 cases, including female 14 cases, male 31cases, synchronous type 15 cases, metechronous type 30 cases. Multiple neoplasms consist of double cancer 33 cases, triple cancer 11 cases, quadrop cancer 1case. The median interval period in double cancer is 58 months. Hematological malignancy consist of non-Hodgkin`s lymphoma 24 cases, Hodgkin`s lymphoma 1 case, myelodysplastic syndrome 6 cases, chronic myelogeneou leukemia 3 cases, multiple myeloma 5 cases, macroglobrinemia 2 cases, acute lymphoblastic leukemia 3 cases, acute myelogeneous leukemia 2 case. Chronic lymphocytic leukemia 1 case. The sites of colon cancer studied 41 cases and results were that ascending colon 7cases, transverous colon 3cases, descending colon 2cases, sigmoid colon 9cases, rectum 8 cases. In a double cancer, 12 cases were preceding colon cancer and 9 cases were preceding hematological malignancy, an interval of the colon cancer precedence cases, the median time was 83M, hematological malignancy precedence cases was 42M. Median survival time is 15M, about cause of death, 21 cases still alive and 24 cases are dead. In 24 cases, hematological malignancy 17 cases, colon cancer 7 cases. Conclusions: In the case of hematological malignancy precedence case, 4 of 9 colon cancer occurred within three years. We should take attention about incidence of other malignancies, particularly those that occur from gastrointestinal tract and serious observation about distant metastasis site, such as liver and lung.