This research studies antecedents of work-life balance and how perceived organizational support as a moderating variable influences work-life balance. In addition, the current situation of primary and secondary school teachers’ work-life balance management was considered.Research data were collected via questionnaires from Chinese teachers. We sent 368 questionnaires to teachers privately available who work in primary and secondary school, and asked them to provide necessary information. 297 questionnaires are usable and return rate is 81.25%.After recording and transforming survey data, the present study did statistical analysis which including factor analysis, correlation analysis, reliability statistics, and hierarchical regression. Findings of the study can be summarized as follow:1. Working hours and work stress are the main task characteristics which will influence work-life balance.2. The frequency of marital conflict will affect work-life balance.3. Leisure time can weaken the conflict of work and family.4. Perceived organizational support can moderate the balance of work and life to some extent.The main contribution of this research is to investigate the antecedents of work-life balance and the moderating effect of perceived organizational support. These research findings shall be quite useful in assisting with relevant authorities when setting up educational reform policies to help teachers get balance of work and life and improve the quality of work and life.