Background () is very common around the world. Sleep-related research is one of the top-funded research projects. Sleep deprivation is known to be a strong for . There are a lot of research on sleep deprivation, however, data regarding and for after sleep deprivation are scarce. The purpose of this prospective trial was to evaluate the and determine for after sleep deprivation.Materials and methodsThis is a multicenter prospective trial. After enrollment, participant characteristics, standardized questionnaires, and tests were analyzed. All subjects with occurring in 2 days sleep deprivation were analyzed.Results59 healthy participants without were included in the trial. 28 out of 59 participants (47.5%) developed to after 2 nights of sleep deprivation. On multivariable analysis, the irregular eating habit and at the compensatory were associated with occurrence OR 8.420 (95% CI 1.46-48.43); P=0.017 and OR 0.837 (95% CI 0.74-0.95), respectively.Conclusion after sleep deprivation occurred to a substantial extent, despite only deprived of 2 nights partial sleep. The of was associated with irregular eating habit and low at the compensatory . Irregular diets in individuals can improve their diets by changing their lifestyle. A lower in sports requires more physical activity, which is an effective way to reduce after sleep deprivation.